华侨大学沙永强--中文主页--首页

个人简介

工作经历： 教育经历：

2024.01~至今，华侨大学，副教授 2010.09~2017.12，重庆大学，生物医学工程，博士

2018.04~2023.12，华侨大学，讲师 2004.09~2008.07，西北大学，生物技术，学士

2008.08~2008.12，山东鲁南制药有限公司，科研人员

研究方向与招生：

1.生物力学与组织再生：关节骨/软骨、肌腱/韧带的损伤修复与再生；

2.肿瘤的发生与生物治疗：食管癌的发生发展、细胞异质性分析、免疫机制等；

3.干细胞治疗：干细胞与机体低氧缺血、炎症等环境的联系，干细胞与组织工程修复。

招收学硕、专硕，欢迎有意愿的同学邮件咨询。

讲授课程：

本科生：生理学、医学机能学实验I、肿瘤学基础、从DNA到基因组；

研究生：细胞工程；

全校通识课：人类健康与生物医学研究进展

主持或参与的科研项目：

1. 横向项目，一种新型可用于关节软骨修复的种子细胞建立及应用研发，主持；

2. 国家自然科学基金青年项目，力生长因子E肽在严重低氧条件下调控前交叉韧带损伤后修复的机理研究，主持；

3. 中央高校基本科研业务费，单细胞测序对胸上、下段食管鳞癌中细胞侵袭、免疫相关的分子机制研究，主持；

4. 华侨大学科研启动经费项目--引进人才类，低氧条件下MGF E肽调控ACL损伤后的修复的机制研究，主持；

5. 国家自然科学基金面上项目，悬浮力学状态对乳腺肿瘤细胞存活和转移的调控及其力学生物学机制，参与；

6. 国家自然科学基金面上项目，低强度超声联合诱导性多潜能干细胞促进损伤周围神经修复的研究，参与。

研究论文：

[1]. Sha Y*, Chen L, Xu C, Zhang B, Hong H, Wang C*. The Roles of IGF-1 and MGF on Nerve Regeneration under Hypoxia- Ischemia, Inflammation, Oxidative Stress, and Physical Trauma. Curr Protein Pept Sci. 2023; 24(2):143-155.

[2]. Yongqiang Sha, Huhai Hong, Wenjie Cai*, Tao Sun*. Single-Cell Transcriptomics of Endothelial Cells in Upper and Lower Human Esophageal Squamous Cell Carcinoma. Current Oncology. 2022. 29: 7680-7694.

[3]. Yongqiang Sha*, Beibei Zhang, Liping Chen, Chunli Wang, Tao Sun*. Dehydrocorydaline Accelerates Cell Proliferation and Extracellular Matrix Synthesis of TNFα-Treated Human Chondrocytes by Targeting Cox2 through JAK1-STAT3 Signaling Pathway. Int J Mol Sci. 2022; 23 (13):7268.

[4]. Yongqiang Sha*, Beibei Zhang, Liping Chen, Huhai Hong, Qingjia Chi. Mechano Growth Factor Accelerates ACL Repair and Improves Cell Mobility of Mechanically Injured Human ACL Fibroblasts by Targeting Rac1-PAK1/2 and RhoA-ROCK1 Pathways. Int J Mol Sci. 2022, 23(8): 4331.

[5]. Yongqiang Sha; Wenjie Cai; Alani mohanad Khalid; Qingjia Chi; Jing Wang; Tao Sun; Chunli Wang. Pretreatment with mechano growth factor E peptide attenuates osteoarthritis through improving cell proliferation and extracellular matrix synthesis in chondrocytes under severe hypoxia. International Immunopharmacology, 2021, 97: 107628.

[6]. Sha Y, Yang L, Lv Y*. MGF E peptide improves ACL repair by inhibiting hypoxia-induced cell apoptosis and accelerating angiogenesis. J Cell Physiol. 2019. 234: 8846-8861.

[7]. Sha Y, Xu Z, Yang L, Lv Y*. ERK1/2 and Akt phosphorylation were essential for MGF E peptide regulating cell morphology and mobility but not proangiogenic capacity of BMSCs under severe hypoxia. Cell Biochem Funct. 2018. 36:155-165.

[8]. Sha Y, Afandi R, Zhang B, Yang L, Lv Y*. MGF E peptide pretreatment improves collagen synthesis and cell proliferation of injured human ACL fibroblasts via MEK-ERK1/2 signaling pathway. Growth Factors. 2017. 35:29-38.

[9]. Sha Y, Lv Y*, Xu Z, Yang L, Hao X, Afandi R. MGF E peptide pretreatment improves the proliferation and osteogenic differentiation of BMSCs via MEK-ERK1/2 and PI3K-Akt pathway under severe hypoxia. Life Sci. 2017. 189:52-62.

[10]. Y Sha, Y Lv*. Effects of MGF E peptide pretreatment on the cell morphology, mobility, proliferation and osteogenic differentiation of BMSCs under severe hypoxia. FEBS J. 2017. 284 (Special Issue, meeting abstract): 126-126.

[11]. 沙永强, 杨力, 吕永钢*.力生长因子E肽对前交叉韧带成纤维细胞活力、迁移和侵袭的影响. 医用生物力学, 2016. 31:227-234.

[12]. Jing Wang, Yongqiang Sha, Tao Sun. m6A modifications play crucial roles in glial cell development and brain tumorigenesis. Front Oncol, 2021, 11: 611660.

[13]. Yuan Yu; Zhiwei Zeng; Danlin Xie; Renliang Chen; Yongqiang Sha; Shiying Huang; Wenjie Cai; Wanhua Chen; Wenjun Li; Rongqin Ke; Tao Sun. Interneuron origin and molecular diversity in the human fetal brain. Nature Neuroscience, 2021, 24: 1745-1756.

[14]. Chunli Wang; Yongqiang Sha; Qingjia Chi; Kang Xu; Sixiang Wang; Li Yang; K L Paul Sung. LOX suppresses the inflammatory response in ACL fibroblasts and promotes tissue regeneration by targeting myotrophin via the nuclear-kappa B pathway. Journal of tissue engineering and regenerative medicine, 2020. 14: 1063-1076.

[15]. Chunli Wang; Qingjia Chi; Yongqiang Sha; Kang Xu; Chunming Xu; Cheng Chen; Wei Huang; Peixing Chen; Peter Chen; Li Yang, K. L. Paul Sung. Mechanical injury and IL-1β regulated LOXs and MMP-1, 2, 3 expression in ACL fibroblasts co-cultured with synoviocytes. Biotechnology Letters, 2020. 42: 1567-1579.

[16]. Xu K, Sha Y, Wang S, Chi Q, Liu Y, Wang C, Yang L. Effects of Bakuchiol on chondrocyte proliferation via the PI3K-Akt and ERK1/2 pathways mediated by the estrogen receptor for promotion of the regeneration of knee articular cartilage defects. Cell Prolif. 2019. 52(5): e12666.

[17]. Wang C, Al-Ani MK, Sha Y, Chi Q, Dong N, Yang L, Xu K. Psoralen Protects Chondrocytes, Exhibits Anti-Inflammatory Effects on Synoviocytes, and Attenuates Monosodium Iodoacetate-Induced Osteoarthritis. Int J Biol Sci. 2019. 15: 229-238.

[18]. He J, Dong L, Xu K, Qian Y, Wang C, Sha Y, et al. Mechano growth factor E peptide inhibits invasion of melanoma cells and up-regulates CHOP expression via endoplasmic reticulum stress. Biotechnol Lett. 2018. 40:205-213.

[19]. Xu K, Sun Y, Mohanad KA, Wang C, Sha Y, et al. Synergistic promoting effects of bone morphogenetic protein 12/connective tissue growth factor on functional differentiation of tendon derived stem cells and patellar tendon window defect regeneration. J Biomech. 2017. 66:95-102.

[20]. Lv Y*, Nan P, Chen G, Sha Y, Xia B, Yang L. In vivo repair of rat transected sciatic nerve by low-intensity pulsed ultrasound and induced pluripotent stem cells-derived neural crest stem cells. Biotechnol Lett. 2015. 37:2497-506.

[21]. 余璨,沙永强,郭盼,陈义梅,等.力生长因子对软组织修复调控作用的研究.生物医学工程学杂志.2015. 32:235-9.

[22]. Lv Y*, Hao X, Sha Y, Yang L. Pretreatment with mechano-growth factor E peptide protects bone marrow mesenchymal cells against damage by fluid shear stress. Biotechnol Lett. 2014. 36:2559-69.

[23]. Lv Y*, Zhao P, Chen G, Sha Y, Yang L. Effects of low-intensity pulsed ultrasound on cell viability, proliferation and neural differentiation of induced pluripotent stem cells-derived neural crest stem cells. Biotechnol Lett. 2013. 35:2201-2212.

专利：

沙永强,张贝贝,赖俊霖,刘浩浩,孙源培，一种力生长因子或其碳端24肽修饰的双层水凝胶支架材料及其制备方法，2023-11-03，中国，202311461476.0。